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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACHE
All Species:
20.91
Human Site:
T280
Identified Species:
35.38
UniProt:
P22303
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22303
NP_000656.1
614
67796
T280
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
Chimpanzee
Pan troglodytes
XP_516857
643
72946
L313
Y
E
A
R
N
R
T
L
N
L
A
K
L
T
G
Rhesus Macaque
Macaca mulatta
NP_001121560
614
67754
T280
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
Dog
Lupus familis
XP_546946
611
67308
T277
G
E
A
R
R
R
A
T
L
L
A
R
L
V
G
Cat
Felis silvestris
Mouse
Mus musculus
P21836
614
68150
T280
G
E
A
R
R
R
A
T
L
L
A
R
L
V
G
Rat
Rattus norvegicus
P37136
614
68178
T280
G
E
A
R
R
R
A
T
L
L
A
R
L
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505841
602
68511
L272
S
E
A
K
N
R
T
L
T
L
A
K
L
L
H
Chicken
Gallus gallus
P36196
767
83002
A273
A
E
G
R
R
R
A
A
A
L
G
R
A
V
G
Frog
Xenopus laevis
NP_001121332
600
68177
E270
Q
E
A
R
R
R
T
E
M
M
G
K
K
L
D
Zebra Danio
Brachydanio rerio
Q9DDE3
634
71980
T271
D
E
A
R
R
R
T
T
K
L
G
K
L
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07140
649
71767
K322
E
K
A
V
E
I
G
K
A
L
I
N
D
C
N
Honey Bee
Apis mellifera
XP_393751
657
73886
I309
E
E
S
I
V
R
G
I
R
L
A
E
A
V
G
Nematode Worm
Caenorhab. elegans
P38433
620
71415
V262
D
V
A
L
A
R
A
V
I
L
Y
N
A
M
K
Sea Urchin
Strong. purpuratus
XP_782113
508
56946
T219
G
G
D
P
N
Q
V
T
I
F
G
E
S
A
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
99.5
92.8
N.A.
88.4
88.5
N.A.
50.6
47.9
59.6
60
N.A.
34.3
39.8
41.2
37.7
Protein Similarity:
100
66.8
99.6
96
N.A.
93
93.6
N.A.
68.2
58
73.4
73.6
N.A.
51.4
56.9
56.9
51.6
P-Site Identity:
100
53.3
100
86.6
N.A.
86.6
86.6
N.A.
40
53.3
33.3
66.6
N.A.
13.3
40
26.6
20
P-Site Similarity:
100
53.3
100
86.6
N.A.
86.6
86.6
N.A.
53.3
53.3
46.6
73.3
N.A.
26.6
53.3
40
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
79
0
8
0
50
8
15
0
58
0
22
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
15
0
8
0
0
0
0
0
0
0
0
0
8
0
8
% D
% Glu:
15
79
0
0
8
0
0
8
0
0
0
15
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
43
8
8
0
0
0
15
0
0
0
29
0
0
0
72
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
8
% H
% Ile:
0
0
0
8
0
8
0
8
15
0
8
0
0
0
0
% I
% Lys:
0
8
0
8
0
0
0
8
8
0
0
29
8
0
8
% K
% Leu:
0
0
0
8
0
0
0
15
22
86
0
0
58
15
0
% L
% Met:
0
0
0
0
0
0
0
0
8
8
0
0
0
8
0
% M
% Asn:
0
0
0
0
22
0
0
0
8
0
0
15
0
0
8
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
8
0
0
15
0
0
0
0
0
0
% Q
% Arg:
0
0
0
65
58
86
0
0
8
0
0
29
0
0
0
% R
% Ser:
8
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
29
50
8
0
0
0
0
8
0
% T
% Val:
0
8
0
8
8
0
8
8
0
0
0
0
0
58
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _